Donation Experience

What are the possible side effects of donating plasma?

Donation Experience

What are the possible side effects of donating plasma?

November 13, 2023

This is one of the most common questions we get at KEDPLASMA, and the short answer is not many. Donating plasma is a low-risk procedure with few or no side effects. Because each donor undergoes a physical exam and medical history survey before entering our program, AND vitals are taken before every donation, we make sure you’re fit to donate!

Occasionally, a donor may experience mild side effects that resolve quickly after donation. In this article, we will go over the few possible side effects of plasma donation and how to counteract them!

Light-headedness or fainting during or after plasma donation

Lightheadedness, dizziness, or, in extreme cases, fainting can sometimes happen during the donation process. Usually, these side effects can be prevented by drinking plenty of water and eating a healthy meal before and after donating your plasma. In most cases, fainting occurs when a donor is fasting before donation or has a very strong fear of needles.

Bruising after plasma donation

As you may know from standard blood tests, needles can sometimes cause some bruising. During plasma donation, some donors might experience minor bruising (although this is uncommon). As you may know, some people’s veins are harder to access than others. This is why we regularly train all of our KEDPLASMA phlebotomists (those amazing employees who take your blood) and match every donor with the right phlebotomist for their vein type. This should make donating even easier than before!


Feeling tired after donating plasma

It’s not uncommon to feel a bit tired after donating plasma. This is your body’s way of responding to losing fluids and proteins. Staying hydrated and having a light snack can help alleviate this. We also recommend not doing strenuous physical activity immediately after donating to give your body some time to recover.

Getting a headache after donating plasma

In some rare cases, donors might feel like they have a headache after donating plasma. This is often due to dehydration. Since plasma contains a lot of water, it is very important to drink a lot of water (around 16 ounces) to prepare and replenish your liquids after donation. Please note that dehydration after donating plasma is usually not severe and passes quickly.


Is donating plasma safe?

Some donors wonder if they’re at risk for disease during the donation process. Absolutely not! For each and every donation, a new, sealed, sterile, one-time-use package is used to collect your plasma.  The needle placement site is sterilized. Your blood never leaves the closed system during the process. 


Plasma donation is safe, easy, and life-changing for patients worldwide who need your help. What are you waiting for? Head into your nearest KEDPLASMA center and donate today!


Do you still have doubts about plasma donation? Our FAQs section will hopefully clear them up. Remember that our medical team and staff is always there to answer all your questions in person.